The besties open on the biggest live question in artificial intelligence policy: can the AI industry regulate itself before the government does it for them? Jason Calacanis, Chamath Palihapitiya, David Sacks, and David Friedberg dig into DeepMind co-founder Demis Hassabis’s proposal for a FINRA-style self-regulatory organization for frontier models, then work through a packed docket that runs from Stripe’s audacious bid for PayPal to Apple’s trade-secrets lawsuit against OpenAI, the xAI Grok Build data leak, the economics of token spend, New York’s first-in-the-nation data center moratorium, foreign influence campaigns shaping American attitudes toward AI, and a science corner on an enzyme that reverses skin aging. You can watch the full episode here.

TLDW

Demis Hassabis proposed a US-led international AI standards body modeled on FINRA: federally overseen, industry funded, run by independent technical experts, with frontier labs submitting models 30 days before release, voluntary at first and mandatory later. The proposal drew broad endorsement across the industry, and the besties debate whether an SRO beats the alternatives. Sacks says he could get on board only under five strict conditions (broad representation including startups and open source, frontier-only review, catastrophic-risk-only scope, voluntary-first, and substitution for rather than addition to new agencies), and warns the plan is an opening bid that Anthropic will use as a stepping stone toward Dario Amodei’s “FAA for AI.” The show then turns to Stripe, Block, and Advent bidding roughly $53 billion for PayPal and what it means for Visa and Mastercard, a wave of AI-native operators reviving stale digital businesses (Bending Spoons, Ryan Cohen), Apple’s lawsuit accusing OpenAI of stealing trade secrets, xAI’s Grok Build silently uploading entire codebases despite a privacy setting, the enormous spread in token costs and Ramp’s new spend controls, Apple’s local-model opportunity with M7 Ultra silicon, America’s looming energy deficit and behind-the-meter power, New York’s hyperscale data center moratorium, alleged Russian and PRC influence operations shaping anti-GMO and anti-data-center sentiment, and a science corner on a Calico enzyme that degrades glycation products to reverse skin aging.

Thoughts

The most important idea in this episode is not the SRO itself but Sacks’s framing of it as an opening bid. His five conditions are a genuinely useful blueprint for how self-regulation could work without curdling into regulatory capture, and his instinct that catastrophic-risk-only scope (cyber and CBRN, not disinformation or “microaggressions”) is the only defensible mandate is the right line to draw. But the deeper point is structural: when an industry walks into government and says “please regulate me,” almost no one in government answers “we’re not qualified.” They say thank you and come back for more. That asymmetry, not any specific rule, is what makes voluntary concessions dangerous. If the SRO is offered for free rather than traded for hard federal preemption written into law, it becomes the floor of a ratchet, not the ceiling of a compromise.

The Anthropic critique running through the segment deserves to be taken on its merits rather than dismissed as a grudge. The claim is specific and falsifiable: that a company now valued in the trillions is funding a state-by-state strategy of one-upmanship, where each new bill is tougher than the last, deliberately producing a patchwork rather than the single national framework everyone claims to want. Whether or not you accept the motive, the mechanism is real and the incentives are legible. If your cost per million tokens is fifty to a hundred times your competitor’s, and cheaper open models plus fine-tuning can cover the vast majority of tasks, then the fastest way to protect a premium price is to make the cheap alternatives legally or practically harder to ship. That is the ladder-pulling thesis, and the token-cost numbers cited on the show are the reason it is not paranoid.

The PayPal bid is the clearest signal of a new operating logic in the capital markets. The interesting question Chamath poses is not “what synergies does PayPal have” but “what is the only thing Advent, Stripe, and Block could build together,” and the answer is a genuine competitor to Visa and Mastercard: hundreds of millions of consumer accounts, Stripe’s merchant relationships and risk infrastructure, Block’s point-of-sale and Cash App, and stablecoin rails from Bridge and PYUSD that can push transactions on-us and bypass the card networks. The antitrust twist is elegant. Define the market as merchant APIs and it looks like consolidation; define it as the card duopoly and the same deal is pro-competitive. This deal would have been dead on arrival two years ago, and the fact that it is live now tells you as much about the regulatory climate as it does about payments.

Underneath the payments story is a broader thesis worth naming: AI-native operators buying mature, founder-less, “stale” digital businesses and modernizing them. Bending Spoons rolling up AOL, Vimeo, Evernote, WeTransfer, and Eventbrite is the template, and Ryan Cohen’s eBay interest is the second dot on the line. The claim is that a modern operator can diagnose where a legacy business overspends, underinvests, and fails to use AI, then fix it with a small team of AI-first executives rather than a McKinsey engagement. It is a persuasive pattern, though PayPal is a harder case than the show admits: a 25-year-old interaction model growing 7% a year is not obviously revived by efficiency alone. Buying 400 million consumer accounts is buying distribution, not a product vision, and the open question is whether anyone can resuscitate the consumer experience rather than just milk it.

The data center segment is where policy, energy, and information warfare collide, and Friedberg’s anti-GMO analogy is the sharpest thing in it. His argument is that manufactured public sentiment, traceable in one case to a foreign media push, can override the scientific and economic merits of a technology for years, and that the anti-data-center movement rhymes with it: closed-loop cooling that uses trivial amounts of water, land-use efficiency that dwarfs almonds and golf courses, and natural gas that burns clean, all drowned out by a moral panic. Whether or not you buy the specific foreign-influence attribution, the underlying tension is real and unresolved. America is staring at a structural electricity deficit while individual blue states treat data centers as a luxury they can refuse, and behind-the-meter power plus edge compute chasing cheap electrons is emerging as the workaround. The moratorium framing matters most here: a “pause” on data centers is not a few months, it is five years once you count ramp-up, and that is long enough to lose a race that may only be measured in months of lead.

Key Takeaways

• Demis Hassabis proposed a US-led international AI standards body modeled on FINRA: federally overseen, industry funded, and run by independent technical experts rather than a new government agency.
• Under the proposal, frontier labs would submit models roughly 30 days before release; the body would assess risk to cybersecurity, national security, and biological threats, update benchmarks quarterly, and could coordinate a development slowdown if the situation demanded it.
• The plan would be voluntary at first and mandatory later, and drew endorsement from a broad set of industry figures including Elon Musk, Sam Altman, Anthropic’s Jack Clark, Sundar Pichai, Satya Nadella, and Jack Dorsey.
• A self-regulatory organization (SRO) like FINRA or the National Futures Association lets the industry set its own testing rules under federal oversight, adjusting faster than a government agency could as the technology changes.
• Sacks laid out five conditions for supporting an SRO: broad representation including startups and open source; review of true frontier models only; scope limited to catastrophic risk (cyber and CBRN); voluntary before mandatory; and a substitute for, not an addition to, new regulatory agencies.
• Sacks argued a government “FAA for AI” would be extreme: type certification for a new aircraft design takes 5 to 9 years, and applying that permission-based model to AI would push release timelines from months to years and lose the race to China.
• He characterized the SRO as an “opening bid” that Anthropic and others would use as a stepping stone toward Dario Amodei’s repeatedly stated goal of an FAA-style regulator, unless it is traded for hard federal preemption written into law.
• The besties cited a Politico report on Anthropic’s alleged state-by-state strategy of one-upmanship, using California’s SB 53 as a model and then ratcheting each subsequent state’s rules tougher, producing a patchwork rather than a single national framework.
• Chamath warned of a “torrent of money” trying to influence both political parties toward some form of regulatory capture, and urged establishing industry rules quickly to supersede the need for a federal agency.
• Stripe and private equity firm Advent, joined by Jack Dorsey’s Block contributing about $17 billion in equity, are jointly bidding roughly $53 billion (about $60 per share) for PayPal, with many expecting the final clearing price closer to $70.
• The strategic logic is a new competitor to Visa and Mastercard: PayPal’s 400-plus million consumer accounts, Stripe’s merchants and risk infrastructure, Block’s point-of-sale and Cash App, and stablecoin rails from Stripe’s Bridge and PayPal’s PYUSD.
• The antitrust outcome hinges on market definition: framed as merchant APIs (Stripe vs. Braintree) it looks anti-competitive, but framed against the Visa/Mastercard duopoly it is pro-competitive, and a deal like this would have been blocked two years ago.
• PayPal peaked around a $322 billion market cap and fell to roughly $30 to 40 billion, which is precisely why it is now attracting bids; Stripe now processes more annual volume than PayPal, but lacks PayPal’s consumer relationship.
• Sacks traced PayPal’s long stagnation to its 2002 eBay acquisition under Meg Whitman, when the founding team was pushed out; the “PayPal mafia” (which Sacks prefers to call the “PayPal diaspora”) formed as a result.
• The deal is framed as part of a wave of AI-native operators reviving mature, founder-less digital businesses, with Bending Spoons (AOL, Vimeo, Evernote, WeTransfer, Eventbrite) as the roll-up template and Ryan Cohen’s eBay interest as another data point.
• M&A is broadly “back on the menu” post-Lina Khan, with deals like Uber acquiring Delivery Hero, driving liquidity and renewed LP appetite for venture alongside SpaceX distributions.
• Apple filed a 41-page lawsuit against OpenAI on July 10th alleging stolen trade secrets tied to OpenAI’s consumer hardware device; OpenAI’s chief hardware officer Tang Tan is a former Apple VP of iPhone design.
• The complaint alleges Apple job candidates were directed to bring actual parts to OpenAI interviews for “show and tell,” and cites a text about accessing network storage; OpenAI has reportedly poached over 400 Apple employees.
• The besties’ rule of thumb: when leaving a company, the only thing you can take is what is in your head; no documents, thumb drives, or files, because Apple rarely litigates and doing so signals something egregious.
• xAI’s Grok Build, powered by Grok 4.5 and running inside Cursor, was reportedly sending users’ entire codebases (potentially including passwords and API keys) to servers despite a privacy setting meant to prevent it; xAI disabled the upload on July 13th and open-sourced the harness.
• Chamath’s takeaway: privacy in AI is fragile and brittle, “zero data retention” cannot be guaranteed, and there are non-obvious data-leak vectors and “trap doors” everywhere, arguing for a stratified ecosystem with independent third-party layers between enterprises and models.
• The “reverse information paradox” (building on Palantir’s Alex Karp) holds that technically capable enterprises want control over their compute, models, weights, data, and “alpha,” via real trust boundaries, private evals, in-tenant learning loops, decoupled orchestration, and the right to fine-tune.
• Cited token costs per million showed a huge spread: roughly $56 on a premium frontier model, about $26 on another, roughly $1.50 for Grok input, around $1 for Elon’s, and about 50 cents for Chinese models, with a claim that 95 to 98% of tasks could run one tier cheaper.
• Ramp CEO Eric Glyman launched token spend management because CFOs cannot see or control AI spend; Ramp customers’ token spend has grown 21x in a year, and someone will eventually miss an earnings quarter on runaway AI opex.
• Engineers optimize for the latest, greatest model while CFOs bear the cost, a misalignment that platforms fine-tuning cheaper open models (like Mira Murati’s Thinking Machines effort) are positioned to exploit.
• Calacanis called Apple a “screaming buy” on local models: rumored M7 Ultra silicon supporting up to 1.5 terabytes of memory could run last-generation frontier-class models locally on a Mac Studio, putting downward pressure on cloud AI pricing.
• Edge compute is fragmenting outward: Sunrun announced distributed data center blocks for homes, and Span partnered with Nvidia, with compute increasingly “chasing energy” like cheap solar and battery power.
• Chamath projected the US will be short 2.5 Californias’ worth of energy by 2050; a recent PJM auction that needed 7 to 8 gigawatts reportedly saw only a fraction show up, underscoring the electricity crunch.
• “Behind the meter” power lets data centers generate their own electricity on owned property, but clean-air permitting is a major obstacle; Elon reportedly used clustered mobile engines and solutions like Bloom Energy to keep projects under personal-use permits (as with Colossus in Memphis).
• New York Governor Kathy Hochul announced the nation’s first statewide moratorium on hyperscale data centers; the besties rebutted her claims on power, land, noise, water, and pollution point by point.
• Modern data centers use closed-loop cooling (one claim compared a typical facility’s water use to a couple of In-N-Out restaurants), occupy trivial land relative to their economic value, generate tax revenue and construction jobs, and are largely powered by clean-burning natural gas.
• Sacks argued the same political forces slowing domestic data centers are also behind chip export controls that would block data centers in allied countries, raising the question of where the buildout can happen at all.
• Friedberg drew an anti-GMO analogy: he argued anti-GMO sentiment tracked the US presence of Russia Today (2010 to 2022) rather than the science, and worried a similar manufactured sentiment is now driving anti-data-center attitudes.
• Sacks cited an OpenAI blog post on PRC-linked influence operations targeting US AI debates, with a congressional investigation reportedly coming, noting China has a clear incentive to slow American AI infrastructure.
• Sacks framed the moment as a “moral panic”: the catastrophes people fear from AI (cyber, job loss) have not materialized, yet the US risks damaging its crown jewel of free-market innovation with premature regulation over hypothetical risks.
• The panel questioned Dario Amodei’s prediction that 50% of entry-level knowledge-worker jobs could disappear within one to five years, arguing the harms have not shown up and only a handful of frontier labs (which already do safety testing and red-teaming) even matter.
• A cited framing of the alleged Anthropic strategy: brand yourself as the safe AI company, ban unsafe AI, then profit; a fresh Chinese model (Kimi K2) was noted as very close to the frontier, suggesting a US lead of only months.
• Science corner: a paper from Google’s Calico and partner Retro-style researchers used AlphaFold plus directed evolution to engineer a novel enzyme that degrades CML, a key advanced glycation end product in the extracellular matrix that drives aging.
• The engineered enzyme cleared 52 to 97% of CML from body proteins in vitro and eliminated 55% of CML from donated elderly human skin, effectively reversing that skin’s biological age toward that of a 31-year-old, pointing first toward a potentially trillion-dollar cosmetic market.

Detailed Summary

Demis Hassabis’s FINRA-Style SRO for AI

DeepMind’s Demis Hassabis published a proposal for a US-led international AI standards body modeled on FINRA, the Financial Industry Regulatory Authority. The design is federally overseen but industry funded and run by independent technical experts. Frontier labs would submit models about 30 days before release, and models would be assessed for risk across cybersecurity, national security, biological threats, and other high-risk domains. Benchmarks would update quarterly, the body could coordinate a development slowdown if warranted, and participation would be voluntary at first and mandatory later. The proposal drew endorsements across the industry, including Elon Musk (who called it thoughtful), Sam Altman, Anthropic’s Jack Clark, Sundar Pichai, Satya Nadella, and Jack Dorsey.

Friedberg explained the SRO concept: bodies like FINRA and the National Futures Association let financial institutions set their own regulatory rules and check one another, under federal oversight but not federal control, reporting up to Senate and House committees. The AI analogy is that many players are all advancing the technology and none wants a single outside regulator dictating tests, especially after California’s earlier AI legislation was, in his telling, outdated by the time it would have taken effect. An SRO can bring in industry experts, adjust tests over time, and operate faster than a new agency. Chamath endorsed it strongly, warning that a “torrent of money” will try to influence both political parties toward regulatory capture, and that establishing rules quickly is the way to avoid that off-ramp while retaining ultimate federal oversight through Commerce and the DOJ.

Sacks’s Five Conditions and the “FAA for AI” Warning

Sacks said he could personally get on board with an SRO because it is “infinitely better” than a new government agency that would become a “DMV for AI,” or worse, Dario Amodei’s “FAA for AI.” He laid out five conditions: the SRO must have broad industry representation including startups and open source (to avoid the three biggest labs capturing it); it should review only true frontier models that represent a step change in capability, not hold up lesser models; its scope should be catastrophic risk only, meaning cyber and CBRN (chemical, biological, radiological, nuclear), not disinformation or speech; it should be voluntary before mandatory, proving it works first; and it must substitute for, not add to, new regulatory structures.

He then explained why an FAA model is extreme: the FAA approves new airplane designs through type certification, which takes 5 to 9 years for a new aircraft and 3 to 5 years for major amendments. Applying permission-based regulation to AI, where new model versions ship every couple of months, would push timelines from months to years and lose the race to a China that will not abide by those rules. His conclusion: if the choice is FAA for AI, DMV for AI, or Hassabis’s SRO, the SRO wins, but it has to be kept “honest and pure,” because otherwise it becomes the opening bid in a coming wave of regulation and a vehicle for massive regulatory capture. He argued that companies making concessions to buy off politicians will only invite the government to come back for more, and that at some point these companies have to grow a spine, draw a line, and demand preemption in exchange.

The Anthropic Regulatory-Capture Debate

Sacks revisited his October claim that Anthropic was running a “sophisticated regulatory capture strategy based on fear-mongering,” arguing that what looked like beating up on a startup now looks different given Anthropic’s trillion-dollar valuation and industry-leading revenue. He cited a Politico piece, “Inside Anthropic’s state-by-state plan to ratchet up AI rules,” describing a strategy of one-upmanship: pass a model bill like California’s SB 53, then make each subsequent state’s rules stricter, deliberately producing a patchwork instead of a single national framework. The panel noted states have strong sovereignty rights (as with self-driving cars) and Anthropic is “winning” in California, Illinois, New York, and other blue states, because government officials rarely refuse an invitation to regulate.

Stripe, Block, and Advent Bid for PayPal

Stripe and private equity firm Advent, joined by Jack Dorsey’s Block contributing about $17 billion in equity, are jointly bidding roughly $53 billion (about $60 per share) for PayPal, with many expecting a final price closer to $70. PayPal still has more than 400 million consumer accounts and processes about $1.7 trillion a year, but its 25-year-old product is growing only about 7% and is seen as legacy. Chamath’s key question was what unique thing this trio could build: a competitor to Visa and Mastercard. Combining PayPal’s consumer accounts, Stripe’s merchant relationships and risk infrastructure, Block’s point-of-sale and Cash App, and stablecoin rails from Stripe’s Bridge and PayPal’s PYUSD would allow far more on-us transactions that bypass the card networks, potentially passing large discounts to merchants and consumers.

Friedberg walked through the deal structure: the $17 billion equity contribution effectively means Stripe and Block sell equity to cash investors, that cash buys PayPal, and the parties end up cross-owning pieces of each other, with the Stripe team the likely operator post-close. The antitrust question turns on market definition: framed as merchant APIs, it is Stripe versus Braintree and looks like consolidation; framed against the Visa/Mastercard duopoly, adding competition is pro-competitive. Sacks noted the deal would have been “the antitrust equivalent of a colonoscopy” two years ago. He also recounted PayPal’s history: acquired by eBay in 2002 under the corporate-minded Meg Whitman, the founding team was pushed out, creating what he prefers to call the “PayPal diaspora” rather than the “PayPal mafia.”

AI-Native Operators and the M&A Wave

Freeberg framed the PayPal and eBay stories as part of an emerging line: AI-native operators buying first-generation digital-native businesses that have gone mature, stale, and founder-less, and that have not yet realized their AI potential or are overspending. Bending Spoons is the roll-up template, having acquired AOL, Vimeo, Evernote, WeTransfer, and Eventbrite and revitalized them from Milan with young, AI-first executives. The panel connected this to Josh Kushner’s and General Catalyst’s roll-ups of traditional services businesses. Calacanis added the macro backdrop: after venture was “on the ropes” under Lina Khan, M&A is “back on the menu,” with deals like Uber acquiring Delivery Hero, renewed LP appetite, and liquidity from SpaceX distributions.

Apple Sues OpenAI Over Trade Secrets

Apple filed a 41-page lawsuit against OpenAI on July 10th alleging stolen trade secrets used to develop OpenAI’s consumer hardware device. OpenAI’s chief hardware officer, Tang Tan, is Apple’s former VP of iPhone design; the complaint alleges he directed Apple job candidates interviewing at OpenAI to bring “actual parts” for “show and tell,” and cites a text from a former Apple engineer about accessing network storage. OpenAI has reportedly poached over 400 Apple employees. Chamath noted Apple rarely litigates, so the suit signals something they found egregious, while cautioning that the facts are alleged and unproven. Sacks declined to opine on the specifics but offered a simple rule: when changing jobs, take nothing but what is in your head, no documents, thumb drives, or files.

The Grok Build Data Leak and AI Privacy

xAI’s Grok Build, powered by Grok 4.5 and running inside Cursor, was reportedly sending users’ entire codebases (not just the files needed for a task, but potentially passwords, API keys, and change logs) to servers, despite a privacy setting meant to stop it. xAI disabled the upload on July 13th, Elon said previously uploaded data was deleted, and xAI open-sourced the harness. Chamath used it to make a larger point tied to his CNBC comments and Alex Karp’s remarks: privacy in AI is fragile and brittle, “zero data retention” cannot truly be guaranteed, and there are non-obvious leak vectors and “trap doors” everywhere. His conclusion is that enterprises need a stratified ecosystem with independent third-party layers between them and the models to manage exposure (a model his firm 8090 uses in its “software factory”).

Sacks connected this to a blog post on the “reverse information paradox,” building on Karp’s point that technically capable enterprises want control over their compute, models, weights, data, and “alpha.” The recipe: establish a real trust boundary with private evals, proprietary learning loops inside the tenant, decoupled orchestration, and the explicit right to fine-tune their own outputs. He described an emerging ecosystem forming alternatives to the monolithic closed model stacks that Anthropic and, to some extent, OpenAI want customers locked into.

Token Economics and Ramp’s Spend Controls

The panel cited a wide spread in cost per million tokens: roughly $56 on a premium frontier model, about $26 on another (similar to a Claude tier), around $1.50 for Grok input, about $1 for Elon’s, and roughly 50 cents for Chinese models. Calacanis said he built a deep-linking podcast player across models on Perplexity and that the new Grok run cost only $11. Ramp CEO Eric Glyman appeared on Squawk Box to launch token spend management, noting Ramp customers’ token spend has grown 21x in a year and that CFOs struggle to see or control spend on an open-ended tab where rates rise with each new model. The takeaway: engineers optimize for the newest model while CFOs bear the cost, and unless that misalignment is controlled, runaway opex becomes a “money-burning furnace” that will eventually cause a public company to miss earnings. The panel argued 95 to 98% of tasks could run one tier cheaper, which is exactly the opportunity platforms fine-tuning cheaper open models (like Mira Murati’s Thinking Machines) are chasing.

Apple’s Local-Model Opportunity and Edge Compute

Calacanis called Apple a “screaming buy,” citing Mark Gurman’s report that a rumored M7 Ultra chip could support up to 1.5 terabytes of memory, double the current ceiling. That would let a Mac Studio run last-generation frontier-class models locally, giving users effectively unlimited tokens on the desktop and putting downward pressure on cloud AI pricing from the likes of Anthropic and OpenAI. Freeberg added that edge compute is fragmenting outward: solar company Sunrun announced distributed data center blocks for homes, and Span partnered with Nvidia. The theme is compute chasing cheap energy, whether excess solar or battery power charged at night.

The Energy Deficit and Behind-the-Meter Power

Chamath warned the US will be short about 2.5 Californias’ worth of energy by 2050, and pointed to a recent PJM auction (serving Pennsylvania, New Jersey, Maryland and other states) that needed 7 to 8 gigawatts but reportedly saw only a fraction show up. He explained “behind the meter” power: rather than drawing grid power from a utility line, a data center generates its own electricity on owned property. The obstacle is clean-air permitting. Solar takes too much space and batteries still need a generation source, so operators use gas. He described Elon clustering mobile 18-wheeler-style engines to keep them under personal-use permits, and newer solutions like Bloom Energy that allow large installations under similar rules, which is how projects like Colossus in Memphis got off the ground.

New York’s Data Center Moratorium

New York Governor Kathy Hochul announced the nation’s first statewide moratorium on hyperscale data centers, citing power draw, land use, water, and noise pollution. The besties rebutted each claim: behind-the-meter power means facilities bring their own electricity rather than competing with residential ratepayers; data centers are highly land-efficient, and New York State is roughly 70 to 80% undeveloped outside the city; noise can be managed with distance; modern facilities use closed-loop cooling (one comparison put a typical facility’s water use at a couple of In-N-Out restaurants, far less than almonds or golf courses); and natural gas is a clean-burning power source. They noted the tax revenue, construction boom, and ongoing jobs data centers create. Sacks cited a theory that Democrats intend the “moratorium” as leverage: pause construction until they can dictate terms, then lift it under a future administration in exchange for a new regulatory agency and speech controls ported from the social-media trust-and-safety agenda. He stressed a moratorium is effectively a five-year pause once ramp-up is counted, and that the same forces slowing domestic builds are pushing chip export controls that would block data centers in allied countries too.

Foreign Influence, Anti-GMO, and the AI Moral Panic

Freeberg drew an extended analogy between anti-data-center sentiment and anti-GMO sentiment. He argued that GMOs were prevalent and uncontroversial from their 1996 launch until anti-GMO sentiment rose in tandem with Russia Today’s US presence (2010 to 2022) and fell after RT was pushed out, and that similar KGB-era “directed measures” influence campaigns can be traced to opposition to nuclear energy in Germany. He cited a poll showing over 50% of Americans believe data centers increase water and electricity costs even where facilities recycle water and generate their own power. Sacks pointed to an OpenAI blog post on PRC-linked influence operations targeting US AI debates, with a congressional investigation reportedly coming, arguing China has a clear incentive to slow US AI infrastructure, kill open source, and constrain cheaper models. Sacks then broadened it to a “moral panic”: the feared catastrophes (cyber, job loss) have not materialized, yet the US risks damaging its crown jewel of free-market innovation over hypothetical risks, questioning Dario Amodei’s prediction that 50% of entry-level knowledge-worker jobs could vanish within one to five years and noting the fresh Chinese model Kimi K2 is close to the frontier.

Science Corner: An Enzyme That Reverses Skin Aging

Freeberg closed with a paper from Google’s secretive longevity startup Calico and a pharma partner focused on the extracellular matrix, the space between cells. Over time, sugars and fats bind to proteins there in a process called glycation, accumulating as advanced glycation end products (chiefly a molecule called CML) that stiffen tissue, cause wrinkles and immobility, and drive inflammation, with nothing in the body to break them down. The researchers used AlphaFold to find a protein that could bind and degrade CML, then applied directed evolution across five recursive cycles, DNA-programming thousands of variants to maximize activity. The engineered enzyme cleared 52 to 97% of CML from body proteins like collagen, casein, and hemoglobin in vitro, and eliminated 55% of CML from donated elderly human skin, effectively reversing that skin’s biological age toward a 31-year-old’s. Open questions remain about delivery (cream, shot, supplement, or an RNA therapy that makes the enzyme inside the body), but the panel expects the first market to be a trillion-dollar cosmetic one, and hailed it as a profound demonstration of AI-driven protein engineering.

Notable Quotes

“The whole industry is going to need to be regulated and I think the industry needs to regulate themselves. That’s the key to this.”

Jason Calacanis, replaying his earlier call for AI self-certification

“If my choices are between FAA for AI or what I would call the DMV for AI, I would much rather go for Demis’ SRO for AI.”

David Sacks, on why self-regulation beats a new government agency

“There’s hardly anyone in government who will ever say, oh no no no, we’re not qualified. Most people in the government will say thank you very much, what else can we take.”

David Sacks, on the asymmetry that makes voluntary concessions dangerous

“What it prevents is a handful of actors using their balance sheets and their capital to essentially pull the ladder up.”

Chamath Palihapitiya, on the point of establishing industry rules quickly

“You are creating a competitor to Visa and Mastercard.”

Chamath Palihapitiya, on the only thing Stripe, Block, and Advent could build together with PayPal

“The only thing you can bring to your new job is what’s in your head. Your memories. But never leave with anything else.”

David Sacks, on avoiding trade-secret disputes when changing employers

“Privacy in AI is very fragile and it’s very brittle. You are leaking information where you don’t know it.”

Chamath Palihapitiya, on the limits of zero-data-retention promises

“Unless you get a control of this and you can directly say how much money you’re making, this is a bridge to nowhere. It is a money burning furnace.”

Chamath Palihapitiya, on uncontrolled enterprise token spend

“We’re on the threshold of destroying the crown jewel of our economy, which is the system of free market innovation that we have.”

David Sacks, on the risk of a premature AI regulatory apparatus

“Number one, brand yourself as a safe AI company. Number two, ban unsafe AI. Three, profit.”

David Sacks, summarizing the strategy he attributes to the “safe AI” positioning

Watch the full conversation here: Can the AI Industry Regulate Itself? on the All-In Podcast.

Related Reading

• FINRA the financial-industry self-regulatory organization that Demis Hassabis’s AI proposal is modeled on.
• AlphaFold (Wikipedia) the protein-structure prediction system behind the age-reversal enzyme discovery in the science corner.
• PayPal Mafia (Wikipedia) background on the founders Sacks calls the “PayPal diaspora.”
• The Founders by Jimmy Soni, the definitive history of PayPal’s founding team and its diaspora.
• Advanced glycation end-products (Wikipedia) the biochemistry of CML and the extracellular-matrix aging the Calico enzyme targets.